Scientists identify protein for treatment of miscarriages

London: Scientists in the UK have discovered a protein which helps embryos stick to the womb and improve treatments for recurrent miscarriages and pre-eclampsia, a pregnancy complication characterised by high blood pressure.

The pioneering study by scientists at the University of Sheffield shows that a protein called Syncytin-1, which was the result of a viral infection of our primate ancestors 25 million years ago, is first secreted on the surface of a developing embryo even before it implants in the womb. This means the protein is likely to play a major role in helping embryos stick to the womb as well as the formation of the placenta.

This fundamental understanding of the earliest stages of human embryo development is crucial for improving current treatments for a variety of stressful complications during pregnancy such as recurrent miscarriages, foetal growth
restriction syndrome and pre-eclampsia - a life-threatening condition of elevated maternal blood pressure during pregnancy. "Recurrent miscarriages, foetal growth restriction syndrome and pre-eclampsia are all significant and very
stressful complications of pregnancy," Professor Harry Moore, Co-Director for the University's Centre for Stem Cell Biology and lead author of the study said.

"Eventually we may be able to develop blood tests based on our results to identify pregnancies that might be at risk and also develop appropriate therapies. There is a lot on the news about the Zika virus infection at the moment and its
devastating effects on foetal development but not all viral infections are necessarily as disastrous," he said. "Amazingly the Syncytin-1 gene is the result of a viral infection of our primate ancestors 25 million years ago.

The viral DNA got into our ancestors genome and was passed on through heredity and the gene involved in the fusion of the virus with cells for infection was co-opted and became Syncytin-1," he said. "Without it humans probably would not have evolved. Surprisingly scientists know much more about the processes of early embryo development in animals than they do in humans," he added.

However, embryo development and reproduction is an aspect of biology where there are fundamental differences between species. Researchers will now investigate whether the level of Syncytin-1 secretion on the pre-implantation embryo is somehow related to outcome of pregnancy in women undergoing IVF.
The study was published today in the journal Human Reproduction.