How vaping could lead to lung disease

Washington: An experimental study has revealed that e-cigarette vapour boosts the production of inflammatory chemicals and disables key protective cells in the lung that keep the air spaces clear of potentially harmful particles.

The vapor impairs the activity of alveolar macrophages, which engulf and remove dust particles, bacteria, and allergens that have evaded the other mechanical defences of the respiratory tract.

The findings prompted the researchers to suggest that while further research is needed to better understand the long-term health impact of vaping on people, e-cigarettes may be more harmful than we think, as some of the effects were similar to those seen in regular smokers and people with chronic lung disease.

Vaping is increasing in popularity, but most of the current body of research has focused on the chemical composition of e-cigarette liquid before it is vaped.

To find out how vaping might change this chemical soup, and what impact this might have, the researchers devised a mechanical procedure to mimic vaping and produce condensate from the vapour. They extracted alveolar macrophages from lung tissue samples provided by eight non-smokers who had never had asthma or chronic obstructive pulmonary disease (COPD).

A third of the cells were exposed to plain e-cigarette fluid, a third to different strengths of the artificially vaped condensate with and without nicotine, and a third to nothing for 24 hours.

The results showed that the condensate was significantly more harmful to the cells than e-cigarette fluid and that these effects worsened as the 'dose' increased.

After 24 hours of exposure, the total number of viable cells exposed to the vaped condensate was significantly reduced compared to the untreated cells, and condensate containing nicotine exaggerated this effect.

The researchers conclude that the vaping process itself can damage vital immune system cells, at least under laboratory conditions.

Lead author Professor David Thickett said, "While e-cigarettes are safer than traditional cigarettes, they may still be harmful in the long term, as the current body of research is in its infancy and not able to answer that question yet."

The full findings are present in the journal Thorax.