Too much or too little sleep puts men at diabetes risk

Washington D.C.: Sleeping either fewer or more hours than average may increase a man's risk of developing diabetes, according to a new study.

More than 29 million people nationwide have diabetes, according to the Endocrine Society's Endocrine Facts and Figures Report. During the last 50 years, the average self-reported sleep duration for individuals has decreased by 1.5 to 2 hours, according to senior author, Femke Rutters. The prevalence of diabetes has doubled in the same time period.

"In a group of nearly 800 healthy people, we observed sex-specific relationships between sleep duration and glucose metabolism," said Rutters. "In men, sleeping too much or too little was related to less responsiveness of the cells in the body to insulin, reducing glucose uptake and thus increasing the risk of developing diabetes in the future. In women, no such association was observed."

The cross-sectional study examined the sleep duration and diabetes risk factors in 788 people. The researchers analyzed a subset of participants in the European Relationship between Insulin Sensitivity and Cardiovascular Disease (EGIR-RISC) study, who were healthy adults ranging in age from 30 to 60 years old. Study participants were recruited from 19 study centers in 14 European countries.

The study found that men who slept the least and the most were more likely to have an impaired ability to process sugar compared to men who slept an average amount, about seven hours. The men at either end of the spectrum had higher blood sugar levels than men who got the average amount of sleep.

Women who slept less or more than average, however, were more responsive to the hormone insulin than women who slept the average amount. They also had enhanced function of beta cells - the cells in the pancreas that produce the hormone insulin. This suggests lost sleep may not put women at increased risk of developing diabetes.

"Even when you are healthy, sleeping too much or too little can have detrimental effects on your health," Rutters said. "This research shows how important sleep is to a key aspect of health - glucose metabolism."

The study appears in the Journal of Clinical Endocrinology & Metabolism.